PRED: a system for the prediction of peptide binding to H2 molecules, a haplotype of the BALB/c mouse

PRED is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2 class I (H2-K, H2-L and H2-D) and class II (I-E and I-A) molecules. The prediction system utilizes quantitative matrices, which were rigorously validated using experimentally determined binders and non-binders and also by in vivo studies using viral proteins. The prediction performance of PRED is of very high accuracy. To our knowledge, this is the first online server for the prediction of peptides binding to a complete set of major histocompatibility complex molecules in a model organism (H2 haplotype). PRED is available at http://antigen.i2r.a-star.edu.sg/predBalbc/.